Emmanuel Adebayor’s first-half strike handed a below-par Arsenal victory, ending Wigan’s five-game unbeaten run.
Wigan came close to opening the scoring when Wilson Palacios’ deflected shot was smartly saved by Manuel Almunia.
Instead, Adebayor broke the deadlock when he slotted home a low effort after collecting a pass from Cesc Fabregas.
Adebayor almost doubled the lead but Chris Kirkland tipped his shot onto the post and Denilson also saw his drive cannon back off the woodwork.
The two sides met in the Carling Cup last month, when Arsenal’s youngsters ran out 3-0 winners against a near full-strength Wigan team.